Effects of neuromuscular blocker drugs
Yesterday I shared information about the SARIN Gas, which was created by the human being since it is not found in the environment, which when transformed into gas is used as a chemical weapon, and has a terrible effect on the neuromuscular junction and the entire nervous system, even causing death by asphyxiation in the unfortunate ones who have contact with this gas.
However, as bad as this is, there are drugs that work in a similar way, but with a beneficial effect for man, even, to a large extent is what has allowed surgery to advance so much and with minimal or no suffering in the patient who requires some surgical process, I speak of one of the drugs used in general anesthesia, the Neuromuscular Blockers.
I am sure that this post will be very informative for you, so I recommend you to read to the end, what I have to tell you will surely interest you.
These drugs are used in conjunction with other drugs at the time of generating general anesthesia in the patient. They are administered into the body intravenously, and must be administered by specialists.
As basic principles of General Anesthesia, in order to achieve it, some very particular characteristics are required. First, it must generate a state of unconsciousness that is reversible, this must be generated by medication, as well as reversion; likewise, it must generate amnesia during the surgical act, which is reversible, that is to say, amnesia must only be present during the surgical act, after the surgery everything must return to normal.
Additionally, and this is where the drugs mentioned in this post come in, the patient must be immobile during the whole surgery. The most commonly used drugs for this purpose are the following:
Atracurio (Tracrium®), Mivacurio (Mivacron®), Succinilcolina (Anectine®), Rocuronio (Zemuron®), Pancuronio (Pavulon®), Vecuronio (Norcuron®).
These drugs have a particular way of acting. They do so very specifically in the skeletal muscles. Before we go on, let us keep in mind that we have three types of muscles in the body, the first of which is the cardiac muscle, which is found in the heart, and s the largest amount of tissue that makes up this organ.
The other type is the smooth muscle, which we find in the blood vessels (veins and arteries), in the intestine, stomach, and other hollow organs, the characteristics that I would like to emphasize of this type is that we cannot control it at our will.
The other, and it is the one on which the drugs in question act, is the skeletal muscle, of which we have the greatest presence in our body. This is the one we have in our arms, legs, abdomen, and that if we can manage and move at will, they move when we want them to. As in the case of the abdominal muscles, the biceps, triceps, etc..
These muscles communicate with the nerves and it is the nerves that make them contract. As I explained in the post I uploaded yesterday, at the end of the neuron acetylcholine is released, to bind to receptors, in this case in muscle receptors, which will cause each muscle cell to "depolarize ", ie, let specific molecules enter and leave others, which causes the cells to contract all together.
Once the acetylcholine has completed its action, it detaches from the receptor and an enzyme acts to neutralize it by a process of hydrolysis. So far this is what normally happens, but What specifically do the drugs used in anesthesia do??
They also bind in that receptor that binds acetylcholine, in the same place as acetylcholine, except that they do not detach. To do so, another drug, the "antidote ", must be administered to reverse this binding. And this is how everything is subsequently restored and returns to normal.
This is the great difference with the SARIN GAS, the same one I spoke about yesterday, that once it binds, in this case to the acetylcholinesterase, it does not detach, it remains bound, generating the great problem at the neuromuscular junction and at the level of the central nervous system.
These anesthetic drugs are not only used for general anesthesia but also for times when it is necessary to place an endotracheal tube in a patient to help him/her breathe. It should also be kept in mind that when these drugs are used, they must be under strict medical supervision to be able to take care of any complications that may arise. And they are not drugs that are used in any space, since they affect many vital functions in the body.
For example, it causes immobility of skeletal muscles, including respiratory muscles, which, if you don't have what is needed to help the patient breathe, the consequences can be very serious indeed.
I hope this post has been informative for you, thank you very much for reading. Any questions or suggestions please leave them in the comments and I will gladly answer them.
Thank you I was much educated but I have a question, most patient even with full anesthesia they still will not relax during the surgery or they will just be calm for few minutes and they will start feeling pain what's the cause?
It is not usual for this to happen, but it can happen in patients who, for example, have enzymes that catalyze the rapid elimination of anesthetic drugs from their system, which leads to the need for a higher dose than usual.
Patients who use drugs also tend to have some resistance to drugs.
Some psychotropic medications can create a greater tolerance in some patients, which, when an anesthetic is administered to them, may warrant a higher dose.
Each case is particular and individual, so there is no single answer.
So it all depends on circumstances that lead to that situation right?
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I always believed and advise people to stay away from any enhancing drugs for the body because of their side effects
It is better to take care of yourself and stay healthy, in fact, to stay away from any drug.
Thank you so much for this piece of information
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