Shedding Light to a Congenital Defect - Embryonic Orofacial Clefts

The formation of the human embryo is a remarkable process, with every part of the body intricately developing itself. Tissues wrap around and meet to shape various body parts, including the face. However, when there is a failure in the meeting of these embryonic tissues, it can result in a condition known as Orofacial cleft

Orofacial clefts are pretty common, affecting approximately 1 in 700 newborns worldwide affecting Asians and Native Americans more than other populations. When I mention Orofacial cleft, I am talking about a cleft lip or palate which can be unilateral or bilateral. Orofacial cleft usually occur in the maxilla bone region, between the upper and the soft pallet.

The human embryonic tissue is made up of Germ Layer which has the Ectoderm which forms the skeleton, the Mesoderm which develops into organs, and the Endoderm which forms the inner lining of the organs. Everything that forms the human body is made up of the three sheets of tissues mentioned above and as embryo forms in week four, the sheet fold on themselves to form the embryo shrimp-tadpole shape which you always see in images.

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The head of the embryo usually have 2 masses which are the frontal nasal prominence which turns to create the frontal bone, the nasal cavity and septum, the middle part of the upper lip, primary palate, and the incisive foramen. Below the nose, there is this indentation known as the philtrum. It is the middle line that you find between your nose and your upper lip. The philtrum is vestigial which is believed to be useful in our ancestors for sniffing and smelling but it is no longer functional.

The second mass is the pharyngeal apparatus which creates the tongue, the mandible, lower lip, the lateral aspect of the upper lip, the soft pallet and rest of the hard pallet. So both tissue masses begin to wrap when creating this structures and a mistake in the fusion leads to a cleft.

Clefts can manifest in three ways and I will like to discuss them. The anatomy of the nasal and oral cavity is made up of the Incisive foramen, the primary palate, and the secondary palate, and a cleft can occur in any of the three structures or can occur in all of them. If there is a cleft in the primary palate then it means there was a failure in the fusion of the frontal nasal prominence meeting the pharyngeal apparatus. If the pharyngeal apparatus on either sides of oral cavity aren't meeting themselves, then it can lead to a cleft.

With cleft, it can lead to an abnormal connection between both the nasal and oral cavity causing food and drink to get into places where they shouldn't get. In cases of newborns they can have feeding problems as well as not having enough suction force to suckle breast. This condition would require surgeries to repair, and in cases where the oral cleft affects the lip, the primary palate, and the secondary palate, then it will require multiple surgeries.

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Infants with cleft lips usually have surgeries done on then in their third month while infants with cleft palate would get surgeries between 6 month and 12 month after birth. Performing surgeries to treat this condition very fast as it can lead to speech problems, breathing problems, digestive problems and other life threatening problems.

Understanding the intricate process of embryonic development sheds light on the challenges associated with Orofacial clefts. The timely recognition and treatment of these conditions through surgical interventions are crucial for ensuring the well-being of affected individuals. Through ongoing research and medical advancements, we continue to strive for effective solutions to address these developmental anomalies and provide a better quality of life for those impacted by Orofacial clefts.

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